Scientific program

Participants arrival

Registration (from 09:00 AM)

10.30 - 11.30 Business meeting for JCCS Editorial Board

11:45 - 13.00 LUNCH

Workshop opening
13:00 - 13:05
Håvard Attramadal
Welcome

13.05 - 13:35
Bernard Perbal
Scnetific Introduction: Where do we come from and where are we going?  

Session I - ECM Proteins in Cell Communication and Signaling
Chairs: Brahim Chaqour and Vivi T. Monsen

13:40 - 14:10 
Donald Gullberg
The role of collagen receptors on Health and Disease

14:10 - 14:40
Raymond Birge
Phosphatidylserine exposure, stress, and cell death: Immune regulation in cancer

14:40 - 15:10 COFFEE BREAK

15:10 - 15:35
Joon Il Jun
Coordinated regulation of intestinal homeostasis and injury repair by CCN1-matricellular signaling

15:35 - 16:00
Vanja Pekovic-Vaughan
A novel role for circadian/NRF2 signalling axis in ECM gene regulation and tissue repair

16:00 - 16:25
Taihao Quan
Develpment in mouse model of dermal aging

18:30 WELCOME RECEPTION AND DINNER with live music at Scandic Holmenkollen Park Hotel

Session II - Vascular Development and Pathophysiology
Chairs: Lester Lau and Håvard Attramadal

08:30 - 09:00 
Anna Zampetaki
The role of CCN2 in microvascular integrity

09:00 - 09:25
Brahim Chaqour
Regulation of microvascular stiffness by CCN2: Implications in microvascular diseases

09:25 - 09:50
Fan E. Mo
The matricellular protein CCN1 induces aortic aneurysms in mice

09:50 - 10:20 COFFEE BREAK

10:20 - 10:45
Zhiyong Lin
CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development

10:45 - 11:10
Mei-Zhen Cui
Lysophosphatidic acid induction of CCN2 expression in vascular mooth muscle cells

Session III - Mechanisms of Disease: Fibrosis and the Matrix 
Chairs: Geoge Bou-Gharios and Satoshi Kubota

11:15 - 11:45
Sylvie Ricard-Blum
Interaction networks of glycosaminoglycans and syndecans: focus on cell-matrix communication

11:45 - 12:10
Andreas Romaine
Cardiac fibrosis is associated with alterations in integrin receptor expression in ageing male rats

12:10 - 13:30 LUNCH

13:30 - 14:00
Morten Karsdal
Tissue degradation and formation in chronic fibroinflammatory disease: Fibroblast activites are essential for outcome of patients

14:00 - 14:25
Vivi Talstad Monsen
The bioactive signaling entity of CCN5 suppresses TGFß-signaling and reverses EMT of pulmonary fibroblasts

14:25 - 14:40
Ole. J. Kaasbøll
Tribune Therapeutics - A CCN Biology Company

14:40 - 15:05
Danqing Min
Deep profiling revealed distinct CD163+ monocytes in diabetes-related complications

15:05 - 15:30
Stephen Twigg
An update on CCNs as markes and mediators in diabetes and its complications with a NASH and lifestyle focus

Social program with Dinner: Boat trip on the Oslo fjord - from harbor at Oslo City hall at 18:00. Bus transportation organized from main entrance of hotel.

Session IV - Tissue Development and Homeostasis
Chairs: Blandine Poulet and Bernard Perbal

08:30 - 08:55
Milos Marinkovic
Exploring the role of CCN1 in aging bone marrow niches: Implications for osteogenic regulation and therapeutical potential

08:55 - 09:20
Satoshi Kubota
Critical role of CCN family members in articular chondrocyte differentiation suggested by an inverse genetic approach

09:20 - 09:45
Masaharu Takigawa
Positive regulation of S-Adenosylmetionine on chondrocyte differentiation via stimulation of polyamine production and the gene expression of cellular comminucation network factor 2, cartilage-specific ECM and its synthesizing enzymes

09:45 - 10:15 COFFEE BREAK

10:15 - 10:40
Nai-Yuan Cheng
Injury-induced CCN1 regulates intestinal regeneration

10:40 - 11:05
Li-Jen Lee
Elevated reactive aggression in forebrain-specific CCN2 knockout mice

11:05 - 11:30
Danqing Min
Effect of exercise intervention on circulating matrix metalloproteinases in people with diabetes and prediabetes

11:30 - 13:00 LUNCH

Session V - Mechanisms of Disease: Cancer and the Matrix
Chairs: Stephen Twigg and Ray Birge

13:00 - 13:30
Bhudev C. Das
Signaling sensitixation of chemoradio-resistant cancer and cancer stem cells for effective targeted therapy

13:30 - 14:05
Celina Kleer
CCN6 reduces breast cancer progression by antagonizing a WNT/b-catenin-EZH2 signaling cascade

14:05 - 14:30 COFFEE BREAK

14:30 - 15:00
Björn Högberg
Origamy DNA and Signaling

15:00 - 15:25
Kathryn Meier
Global Proteomics Analysis of the Role of CCN1 in Prostate Cancer Cells

15:25 - 15:50
Gary Fisher
Mouse fibroblast-specific expression of matrix metalloproteinase-1 accelerates dermal aging and promotes skin tumor formation

Free evening

Special JCCS Executive Board Meeting

Session VI
Chair: Bernard Perbal

08:45 - 09:00
Bernard Perbal
ICCNS Award Presentation

09:00 - 09:45
Katia Scotlandi
ICCNS AWARD Lecture
Ewing's sarcoma: embracing complexity to identify new therapeutic vulnerabilities

Educational lecture

09:50 - 10:20
Gabriele Marinello
Qeios Academic Publishing - Research you can trust

10:20 - 10:45 COFFEE BREAK

10:45 - 11:00
Announcements
Future ICCNS meetings

11:00 - 11:30
Håvard Attramadal
Scientific conclusions

12:00 LUNCH

Departure of the participants